Supplementary Table 4.  List of the 100 protein sequences selected randomly from the Swiss-Prot

 database (http://www.expasy.org/sprot/). These proteins are unlikely to interact with DNA or RNA.

Swiss-Prot ID

Functional annotation

ANSP_ECOLI

L-asparagine permease (L-asparagine transport protein)

APE1_SCHPO

Aminopeptidase I (EC 3.4.11.-)

APGM_THEAC

2,3-bisphosphoglycerate-independent phosphoglycerate mutase (EC 5.4.2.1)

APOH_BOVIN

Beta-2-glycoprotein I precursor (Apolipoprotein H)

ARGI_STAAM

Arginase (EC 3.5.3.1)

ATKA_HALSA

Potassium-transporting ATPase A chain (EC 3.6.3.12)

CADH_MAIZE

Cinnamyl-alcohol dehydrogenase (EC 1.1.1.195) (CAD)

CAHZ_BRARE

Carbonic anhydrase (EC 4.2.1.1) (Carbonate dehydratase)

CAID_SALTI

Carnitinyl-CoA dehydratase (EC 4.2.1.-) (Crotonobetainyl-CoA hydratase)

CCPR_YEAST

Cytochrome c peroxidase, mitochondrial precursor (EC 1.11.1.5) (CCP)

CCR10_HUMAN

C-C chemokine receptor type 10 (C-C CKR-10) (CCR-10) (G-protein coupled receptor 2)

CD2A1_MOUSE

Cyclin-dependent kinase inhibitor 2A (Cyclin-dependent kinase 4 inhibitor A) (CDK4I)

CDO_SCHJA

Cysteine dioxygenase (EC 1.13.11.20) (CDO)

CDPK1_ARATH

Calcium-dependent protein kinase, isoform AK1 (EC 2.7.1.-) (CDPK)

CDR_STAAM

Coenzyme A disulfide reductase (EC 1.8.1.14) (CoA-disulfide reductase) (CoADR)

CDSA_RICPR

Phosphatidate cytidylyltransferase (EC 2.7.7.41) (CDP-diglyceride synthetase)

CEMA_ORYSA

Chloroplast envelope membrane protein

CESA8_ARATH

Cellulose synthase A catalytic subunit 8 [UDP-forming] (EC 2.4.1.12) (AtCesA-8)

CFTR_HUMAN

Cystic fibrosis transmembrane conductance regulator (cAMP-dependent chloride channel)

CH3L1_PIG

Chitinase-3-like protein 1 precursor (38 kDa heparin-binding glycoprotein)

CHIC_SECCE

Basic endochitinase C precursor (EC 3.2.1.14) (Rye seed chitinase-c) (RSC-c)

CHLB_CHLMO

Light-independent protochlorophyllide reductase subunit B (EC 1.18.-.-)

CHLE_HUMAN

Cholinesterase precursor (EC 3.1.1.8) (Acylcholine acylhydrolase)

CHLN_ADICA

Light-independent protochlorophyllide reductase subunit N (EC 1.18.-.-)

CHOMT_MEDSA

Isoliquiritigenin 2'-O-methyltransferase (EC 2.1.1.-) (Chalcone O-methyltransferase)

CHS2_SOYBN

Chalcone synthase 2 (EC 2.3.1.74) (Naringenin-chalcone synthase 2)

CHSS2_MOUSE

Chondroitin sulfate synthase 2 (EC 2.4.1.175)

CIMA_METAC

(R)-citramalate synthase (EC 2.3.3.-)

CISY3_YEAST

Citrate synthase 3 (EC 2.3.3.1)

CITN_SALPU

Citrate-sodium symport (Citrate transporter) (Citrate carrier protein)

CLAT_MOUSE

Choline O-acetyltransferase (EC 2.3.1.6) (CHOACTase) (Choline acetylase) (ChAT)

CLCA_RHOOP

Chlorocatechol 1,2-dioxygenase (EC 1.13.11.-)

CLCB_RAT

Clathrin light chain B (Lcb)

CLCKA_RAT

Chloride channel protein ClC-Ka (Chloride channel Ka) (ClC-K1)

CLIC6_RABIT

Chloride intracellular channel 6 (Parchorin)

CLPP1_CHLPN

ATP-dependent Clp protease proteolytic subunit 1 (EC 3.4.21.92) (Endopeptidase Clp 1)

CLS_BACPF

Cardiolipin synthetase (EC 2.7.8.-) (Cardiolipin synthase) (CL synthase)

COX1_PONPA

Cytochrome c oxidase subunit 1 (EC 1.9.3.1) (Cytochrome c oxidase polypeptide I)

COX3_FELCA

Cytochrome c oxidase subunit 3 (EC 1.9.3.1) (Cytochrome c oxidase polypeptide III)

CP17A_HUMAN

Cytochrome P450 17A1 (EC 1.14.99.9) (CYPXVII) (Steroid 17-alpha-monooxygenase)

CP2B4_RABIT

Cytochrome P450 2B4 (EC 1.14.14.1) (CYPIIB4)

CYB_ANTNA

Cytochrome b

DAPB_CAMJE

Dihydrodipicolinate reductase (EC 1.3.1.26) (DHPR)

DGTP_PSEAE

Deoxyguanosinetriphosphate triphosphohydrolase (EC 3.1.5.1) (dGTPase)

FABD_BACSU

Malonyl CoA-acyl carrier protein transacylase (EC 2.3.1.39) (MCT)

FAD3E_ARATH

Omega-3 fatty acid desaturase, endoplasmic reticulum (EC 1.14.19.-)

FADL_SALTY

Long-chain fatty acid transport protein precursor (Outer membrane fadL protein)

FANCL_HUMAN

Ubiquitin ligase protein FANCL (EC 6.3.2.-) (Fanconi anemia group L protein)

G6PI_RHIME

Glucose-6-phosphate isomerase (EC 5.3.1.9) (GPI) (Phosphoglucose isomerase)

GBB5_PONPY

Guanine nucleotide-binding protein beta subunit 5 (Transducin beta chain 5) (Gbeta5)

GBRR3_RAT

Gamma-aminobutyric-acid receptor rho-3 subunit precursor (GABA(A) receptor)

GLB3_CHITH

Globin CTT-III precursor (Erythrocruorin III)

GLGA1_BRAJA

Glycogen synthase 1 (EC 2.4.1.21) (Starch [bacterial glycogen] synthase 1)

GLGB_BURPS

1,4-alpha-glucan branching enzyme (EC 2.4.1.18) (Glycogen branching enzyme)

GNAQ_XENLA

Guanine nucleotide-binding protein G(q), alpha subunit

HEM6_MOUSE

Coproporphyrinogen III oxidase, mitochondrial precursor (EC 1.3.3.3)

HIS7_BIFLO

Imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19) (IGPD)

IDH3G_RAT

Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial precursor (EC 1.1.1.41)

KAD_THENE

Adenylate kinase (EC 2.7.4.3) (ATP-AMP transphosphorylase)

KHSE_PHOLL

Homoserine kinase (EC 2.7.1.39) (HSK) (HK)

LCAP_HUMAN

Leucyl-cystinyl aminopeptidase (EC 3.4.11.3) (Cystinyl aminopeptidase) (Oxytocinase)

MCRB_METVA

Methyl-coenzyme M reductase beta subunit (EC 2.8.4.1)

MDH_SILPO

Malate dehydrogenase (EC 1.1.1.37)

MLE1_MUGCA

Myosin light chain 1, skeletal muscle isoform (A1 catalytic) (Alkali) (LC-1) (LC1)

MMP26_HUMAN

Matrix metalloproteinase-26 precursor (EC 3.4.24.-) (MMP-26) (Matrilysin-2) (Endometase)

MSBA_PASMU

Lipid A export ATP-binding/permease protein msbA

NU1M_BRAVA

NADH-ubiquinone oxidoreductase chain 1 (EC 1.6.5.3) (NADH dehydrogenase subunit 1)

NUOG_BUCBP

NADH-quinone oxidoreductase chain G (EC 1.6.99.5) (NADH dehydrogenase I, chain G)

PDXT_CORDI

Glutamine amidotransferase subunit pdxT (EC 2.6.-.-)

PELA_EMENI

Pectate lyase precursor (EC 4.2.2.2)

PHAE_RHIME

K(+)/H(+) antiporter subunit E (pH adaptation potassium efflux system protein E)

PHEB1_SYNPY

C-phycoerythrin class I beta chain

PHNC_STAAM

Phosphonates import ATP-binding protein phnC (EC 3.6.3.28)

PHOR_BACSU

Alkaline phosphatase synthesis sensor protein phoR (EC 2.7.3.-)

PP4C_RABIT

Serine/threonine protein phosphatase 4 catalytic subunit (EC 3.1.3.16) (PP4C)

PTRB_ECOLI

Protease II (EC 3.4.21.83) (Oligopeptidase B)

PYRE_BORBR

Orotate phosphoribosyltransferase (EC 2.4.2.10) (OPRT) (OPRTase)

RAG1_KLULA

Low-affinity glucose transporter (Hexose transporter 1)

RAM2_YEAST

Protein farnesyltransferase/geranylgeranyltransferase type I alpha subunit (EC 2.5.1.58)

SHARK_DROME

Tyrosine-protein kinase shark (EC 2.7.1.112)

SIA4A_HUMAN

CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase (EC 2.4.99.4)

SIAH2_XENLA

Ubiquitin ligase SIAH2 (EC 6.3.2.-) (Seven in absentia homolog 2) (Xsiah-2)

SID1_USTMA

L-ornithine 5-monooxygenase (EC 1.13.12.-) (L-ornithine N5-oxygenase)

SILE_SALTY

Silver-binding protein silE precursor

SL9A6_HUMAN

Sodium/hydrogen exchanger 6 (Na(+)/H(+) exchanger 6) (NHE-6)

SMTA_ASTBI

Selenocysteine methyltransferase (EC 2.1.1.-) (SECYS-methyltransferase) (SECYS-MT)

SNAT_SHEEP

Serotonin N-acetyltransferase (EC 2.3.1.87) (Aralkylamine N-acetyltransferase) (AA-NAT)

SRPG_SYNP7

Cysteine synthase, plasmid (EC 2.5.1.47) (O-acetylserine sulfhydrylase)

THIO_TREPA

Thioredoxin (TRX)

THIP_ECOLI

Thiamine transport system permease protein thiP

THRC_PSEAE

Threonine synthase (EC 4.2.3.1)

THTR_AZOVI

Thiosulfate sulfurtransferase (EC 2.8.1.1) (Rhodanese-like protein)

THYX_STRCO

Thymidylate synthase thyX (EC 2.1.1.148) (TS) (TSase)

TRN2_DATST

Tropinone reductase-II (EC 1.1.1.236) (TR-II)

UFOG5_MANES

Flavonol 3-O-glucosyltransferase 5 (EC 2.4.1.91)

URE1_STRSL

Urease alpha subunit (EC 3.5.1.5) (Urea amidohydrolase)

VHT1_YEAST

Vitamin H transporter (H+/biotin symporter)

XYNA_PRERU

Endo-1,4-beta-xylanase A precursor (EC 3.2.1.8) (Xylanase A)

YDIS_ECOLI

Electron transfer flavoprotein-quinone oxidoreductase ydiS (EC 1.5.5.-)

ZUPT_STRMU

Zinc transporter zupT